Gum Disease Linked to Alzheimer’s: Study Finds Oral Bacteria Can Impact Brain Cells


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In a study, it was discovered that gum disease alters the microglial cells that protect the brain from amyloid plaque-induced cell death.


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Periodontitis Overview 

Gum disease, also referred to as periodontitis, is a serious gum infection that damages the soft tissue surrounding teeth. Its pronunciation is per-e-o-don-TIE-tis. The bone that supports your teeth could be destroyed by periodontitis if left untreated.This could lead to tooth loss or tooth sensitivity.

Although frequent, periodontitis is typically preventable. Poor oral and dental hygiene is the main cause of this frequent occurrence. Brush your teeth at least twice a day, floss every day, and schedule routine dental exams to help avoid periodontitis or increase your chances of a successful treatment.

Key factor of Gum Disease Linked to Alzheimer’s: Study Finds Oral Bacteria Can Impact Brain Cells 

Name of the topic Gum Disease Linked to Alzheimer’s: Study Finds Oral Bacteria Can Impact Brain Cells
Disease  Gum disease 
Medical terminology Periodontitis
Symptoms  Swollen gums, sore in gums and many more

About Gum Disease Linked to Alzheimer’s: Study Finds Oral Bacteria Can Impact Brain Cells 

Researchers linked gum disease to amyloid plaque development in Alzheimer’s disease, finding that gum disease affects microglial cells, which protect the brain from cell death.The study reveals oral bacteria enter the brain and neuroinflammation’s role in Alzheimer’s disease, affecting memory and thinking skills.

Study investigates oral bacteria’s potential to alter brain cells, revealing overstimulation and overabsorption of microglial cells, responsible for breaking down amyloid plaque. “They essentially gained weight. Plaque formations could no longer be digested, according to Kantarci.

Gum disease causes lesions between teeth and gums, impacting overall health. Lesion resembles palm size, allowing germs to spread to other body regions.Microorganisms cross blood-brain barrier, activate microglial cells, and protect brain surfaces.

Scientists monitored periodontal disease in mice, found bacteria causing brain damage through oral bacteria. Brain microglial cells exposed to oral bacteria induced neuroinflammation and altered amyloid plaque response.

Kantarci suggests understanding oral bacteria triggers neuroinflammation for specialized treatments. Study highlights managing oral inflammation from periodontal disease to prevent neuroinflammation and neurodegeneration.

Symptoms of Gum disease

Gums that are in good health are firm and tightly abut teeth. Healthy gums can be any colour.They can be light pink in some persons and dark pink and brown in others.

Periodontitis symptoms can include

  • Puffy or swollen gums.
  • Bright crimson, dark red, or dark purple gums.
  • When touched, the gums feel sore.
  • Easy to bleed gums.
  • After brushing your teeth, a pink toothbrush.
  • When brushing or flossing your teeth, spitting blood.
  • Breath that is continually bad.
  • Your teeth and gums have been pulled up.
  • Tooth loss or tooth sensitivity.
  • painful chewing.
  • New, dark triangle-shaped gaps that form in between your teeth.
  • Receding gums are gums that peel away from your teeth, giving the appearance that your teeth are longer than usual.
  • A modification in how your teeth bite together.

Causes of Gum disease 

Plaque, a sticky layer of bacteria, is a common cause of periodontitis. Mouth bacteria cause plaque formation from food carbohydrates and sugars; daily brushing and flossing reduces but can re-increase growth.

Gingivitis, a mild gum disease caused by plaque, causes inflammation and swelling of gum tissue at the tooth base. Addressing before bone loss is crucial.

Periodontitis is caused by persistent gum inflammation, causing deep pockets between teeth, causing bone and tissue loss. Untreated inflammation can lead to tooth loss and immune system issues.

Prevention from Gum disease 

Developing good oral and dental hygiene habits is the best strategy to stave off periodontitis. Start this regimen early in life and stick with it.

Oral hygiene

This involves cleaning at least once daily and brushing your teeth for two minutes at least twice daily, preferably in the morning and before night. You can remove the bacteria and loosening food particles by flossing first before brushing. In addition to keeping your teeth and gums healthy, good oral hygiene gets rid of the bacteria that cause periodontal disease.

Regular trips to the dentist

Visit your dentist every six to twelve months for cleanings. You may require professional cleaning more frequently if you smoke, take certain medications, have dry mouth, or have other risk factors for periodontitis.

Alzheimer’s disease: 

This is also known as Senile Dementia. A chronic condition that impairs memory and other crucial mental processes.

The degradation and death of brain cell connections and the cells themselves eventually results in the loss of memory and other essential mental abilities.


  • Over a million cases annually (India)
  • Although there is no cure for this illness, medication can help.
  • Requires a diagnosis from a doctor
  • No need for imaging or laboratory tests
  • Chronic: lasting for years or forever


  • Requires a diagnosis from a doctor
  • Confusion and memory loss are the main signs and symptoms.
  • Problem in managing complicated jobs with logic.
  • Language.
  • Recognising the link between space and visual form.
  • Personality and behaviour.

Information By – Supriyo Mishra

Meet Supriyo Mishra, your go-to source for all things tech and innovation at ReadNeo. As a tech aficionado and writer, I'm on a mission to unravel the latest trends, gadgets, and breakthroughs in the digital realm. Join me in exploring the ever-evolving world of technology and discover how it's shaping our lives and the future. Welcome to a digital adventure with ReadNeo!


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